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KMID : 0604219950020010157
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Korean Journal Investigative Dermatology
1995 Volume.2 No. 1 p.157 ~ p.162
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Endothelin-1 Expression on PUVA-Treated Pigmented Patches in Vitiligo
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이윤주
김재원/서성준/홍창권/노병인
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Abstract
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Recently several investigators demonstrated that human kerationcytes produce and secrete endothelin (ET)-1 which can be a strong mitogen for melanocytes. UVB exposure extremely stimulates the paracrine linkage of endothelins, indicating them to
be
the
keratinocyte-derived intrinsic mitogens in UVB-melanogenesis.
Thel study is designed to elucidate whether expression of EF-1 is increased by UV irradiation and related to UV induced pigmentation in vitiligo.
Immunohistochemical staining using a monoclonal antibody against mouse ET-l antigen was performed in the biopsied specimens of the vitliginous lesions and pigmented patches taken before and after systemic PUVA therapy from 5 patients with
vitiligo.
Immunohistochemical staining for ET-l were not stain in vitiliginous lesions except one, but entire basal cell layers or entire epidermis were stained in pigmented patches developed after U irradiation.
The above results suggest that ET-l may be play a certain role in pigmentation.
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KEYWORD
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